Spirulina Inhibits Tumorigenic Potential of Pancreatic Cancer Cells |

According to the recent research findings with respect to Pancreatic Cancer Cells,  done by the China Pharmaceutical University. The research findings found out that pancreatic adenocarcinoma (PDA) is one of the most lethal human malignancies, and unresponsive to current chemotherapies.

In-vivo and Invitro therapeutic results of Phycocyanin extracts of spirulina in inhibiting Pancreatic cancer:
Considering the anti-healing results of Spirulina in healing different diseases. Researcher’s  extracted phycocyanin pigments from spirulina. Phycocyanin has an anti-PDA agent in vivo and in-vitro. Which showed effective inhibition of  the pancreatic cancer cell proliferation in vitro and xenograft tumor growth in vivo.

Mechanism of Phycocyanin on autophagic cell death:
Phycocyanin induces G2/M cell cycle arrest, apoptotic and autophagic cell death in PANC-1 cells. Mechanistically, cell death induced by phycocyanin is the result of cross-talk among the MAPK, Akt/mTOR/p70S6K and NF-κB pathways. Phycocyanin is able to induce apoptosis of PANC-1 cell by activating p38 and JNK signaling pathways while inhibiting Erk pathway. On the other hand, phycocyanin promotes autophagic cell death by inhibiting PI3/Akt/mTOR signaling pathways. Furthermore, phycocyanin promotes the activation and nuclear translocation of NF-κB, which plays an important role in balancing phycocyanin-mediated apoptosis and autosis.

Conclusion: 
In conclusion, the studies demonstrate that phycocyanin exerts anti-pancreatic cancer activity by inducing apoptotic and autophagic cell death, thereby identifying phycocyanin extracts of spirulina as a promising anti-pancreatic cancer agent.

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