Antioxidant effects of Spirulina supplement against lead Toxicity which causes hepatic injury:
- Research reviewed by Sidmans Spirotech

Lead toxicity:
Lead is a toxic metal that induces a wide range of behavioral, biochemical and physiological effects in humans. Oxidative damage has been proposed as a possible mechanism involved in lead toxicity.

Based upon the biochemical properties of Spirulina, The present research study reveals the antioxidant activities of Spirulina supplement against lead acetate -induced hepatic injury in rats.

Research technique:
Five groups of rats were used in this study, with the administration of different concentration of lead acetate with different groups of rats.

Lead intoxication effects: Lead intoxication resulted in a significant increase in serum alanine transaminae (ALT), aspartate transaminae (AST) activities, liver homogenate tumor necrosis factor-α (TNF-α), caspase-3, malondialdehyde (MDA), nitric oxide (NO) levels and a significant decline of total serum protein, liver homogenate reduced glutathione (GSH) level and superoxide dismutase (SOD) activity.

Spirulina Impact on Lead intoxication:
With respect to the biochemical studies and toxicity analytical reports different doses of Spirulina supplements succeeded to improve the biochemical parameters of serum and liver and prevented the lead acetate-induced significant changes on plasma and antioxidant status of the liver. Different doses of Spirulina supplement had the same anti-apoptotic activity. The research study concludes that Spirulina supplement had protective, antioxidant and anti-apoptotic effects on lead acetate-induced hepatic damage.

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