Advanced optimized chemical formulation to prepare more additive comprehensive nutrition based tablets using naturally derived Spirulina and Moringa Olefera

A review Article from Sidmans Spirotech Nutraceuticals India Pvt. Ltd
 
         We all know that “health is Wealth”, But with respect to the present scenario of human lifestyle and food habits, If our health is supplemented with plant derived Nutraceuticals and Probiotics along with a balanced food habits, then our body will retains wealth.

As with respect to the recent publication from Saudi journals of biological Sciences, They have designed a new phyto chemical nutrient formulation tablets using Moringa Olifera leaves and Spirulina. Acchording the research conducted by them on Individuals who are defected with lack of nutrients, These new phyto chemical formulation showed more balanced impact on the defected individuals.   

Method: The nutrient composition of M. oleifera leaves and spirulina ratio was determined based on the raw materials, and the choice of microcrystalline cellulose, sodium salt of caboxy methyl cellulose (CMC), magnesium stearate excipient, through single factor and orthogonal experiment.
The phyto nutrient chemical formulation was prepared using “Powder direct compression technology (PDCT)”.

Results: The best ratio of raw material for the M. oleifera leaves powder: spirulina powder was 7:3, the best raw materials for the tablet formulation was 88.5%, 8.0% microcrystalline cellulose, CMC 2.0%, stearin magnesium 1.5%, the optimum parameters for the raw material crushing 200–300 mesh particle size, moisture content of 7%, tableting pressure 40 kN. 

Conclusion: Through formulation and process optimization, we can prepare more comprehensive and balanced nutrition M. oleifera and spirulina complex tablets, which has showed a proven health impact on defected individuals. Its sheet-shaped appearance, piece weight variation, hardness, friability, disintegration and other indicators have reached the appropriate quality requirements.
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Health Benifits of Spirulina

Health Benifits of Spirulina
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♣Rich in Protein
♣Rich in Vitamins_and Minerals
♣Antidote to Poisoning
♣Fights Allergies
♣Regulates Blood Pressure
♣Manages Cholesterol
♣Helps With Cancer, Especially Oral
♣Boosts Immunity
♣Improves Memory and Academic Performance
♣Protects the Brain
♣Powerful Antioxidants
♣Anti-Inflammatory Properties
♣Protects LDL Cholesterol from Becoming Oxidized
♣Effective Against Anemia
♣Improves Muscle Strength and Endurance
♣Helps with Regulating Sugar Levels
♣Helps Fight Liver Diseases
♣Helps with Weight Loss
♣Fights PMS Symptoms
♣Eliminates Candida
♣Helps Manage HIV/AIDS
♣Keeps Skin Healthy
♣May Treat Hepatitis
♣Preserves Bone Health
♣Reduces Radiation Sickness

Note : We will learn each health benifit per day and share our research,If you know more about any benefit share your information into this group by commenting.

Spirulina Inhibits Tumorigenic Potential of Pancreatic Cancer Cells |

According to the recent research findings with respect to Pancreatic Cancer Cells,  done by the China Pharmaceutical University. The research findings found out that pancreatic adenocarcinoma (PDA) is one of the most lethal human malignancies, and unresponsive to current chemotherapies.

In-vivo and Invitro therapeutic results of Phycocyanin extracts of spirulina in inhibiting Pancreatic cancer:
Considering the anti-healing results of Spirulina in healing different diseases. Researcher’s  extracted phycocyanin pigments from spirulina. Phycocyanin has an anti-PDA agent in vivo and in-vitro. Which showed effective inhibition of  the pancreatic cancer cell proliferation in vitro and xenograft tumor growth in vivo.

Mechanism of Phycocyanin on autophagic cell death:
Phycocyanin induces G2/M cell cycle arrest, apoptotic and autophagic cell death in PANC-1 cells. Mechanistically, cell death induced by phycocyanin is the result of cross-talk among the MAPK, Akt/mTOR/p70S6K and NF-κB pathways. Phycocyanin is able to induce apoptosis of PANC-1 cell by activating p38 and JNK signaling pathways while inhibiting Erk pathway. On the other hand, phycocyanin promotes autophagic cell death by inhibiting PI3/Akt/mTOR signaling pathways. Furthermore, phycocyanin promotes the activation and nuclear translocation of NF-κB, which plays an important role in balancing phycocyanin-mediated apoptosis and autosis.

Conclusion: 
In conclusion, the studies demonstrate that phycocyanin exerts anti-pancreatic cancer activity by inducing apoptotic and autophagic cell death, thereby identifying phycocyanin extracts of spirulina as a promising anti-pancreatic cancer agent.

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Antioxidant effects of Spirulina supplement against lead Toxicity which causes hepatic injury:
- Research reviewed by Sidmans Spirotech

Lead toxicity:
Lead is a toxic metal that induces a wide range of behavioral, biochemical and physiological effects in humans. Oxidative damage has been proposed as a possible mechanism involved in lead toxicity.

Based upon the biochemical properties of Spirulina, The present research study reveals the antioxidant activities of Spirulina supplement against lead acetate -induced hepatic injury in rats.

Research technique:
Five groups of rats were used in this study, with the administration of different concentration of lead acetate with different groups of rats.

Lead intoxication effects: Lead intoxication resulted in a significant increase in serum alanine transaminae (ALT), aspartate transaminae (AST) activities, liver homogenate tumor necrosis factor-α (TNF-α), caspase-3, malondialdehyde (MDA), nitric oxide (NO) levels and a significant decline of total serum protein, liver homogenate reduced glutathione (GSH) level and superoxide dismutase (SOD) activity.

Spirulina Impact on Lead intoxication:
With respect to the biochemical studies and toxicity analytical reports different doses of Spirulina supplements succeeded to improve the biochemical parameters of serum and liver and prevented the lead acetate-induced significant changes on plasma and antioxidant status of the liver. Different doses of Spirulina supplement had the same anti-apoptotic activity. The research study concludes that Spirulina supplement had protective, antioxidant and anti-apoptotic effects on lead acetate-induced hepatic damage.

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Main factors affecting the Growth rate of Spirulina
- Research reviewed by #Sidmans#Spirotech

According to the recent findings and investigations from Dr. Wen-qing Shi and group with respect to light and electron optics interventions with #spirulina, Regarding to the growth aspects showed a very good promising results in terms increase in an overall biomass of the product.
This study was mainly done/ designed based on the effect of culture conditions (temperature and pH), culture medium, light source (single and combined light source) and the corresponding exposure time on the growth rate of spirulina.
As with respect to the base finding results, The optimal temperature and pH for the growth of Spirulina were 30 °C and pH 9.5–10.0, respectively.

Effect of chemical composition as a culture medium on the growth rate of Spirulina:with 10 g/L of NaHCO3, 2 g/L of NaNO3, 0.6 g/L of KH2PO4, 0.2 g/L of MgSO4·7H2O and 1.2 g/L of K2SO4 achieved the best growth rate of Spirulina.

Impact on Light exposure:
Comparing the growth analytics of Spirulina with respect to Test groups and control group cultures, When the test cultures being exposed to the red light (wavelength, 620–630 nm), blue light (wavelength, 465–475 nm) and green light (wavelength, 522–532 nm), the maximum dry matter contents of Spirulina were 1.346 g/L, 1.179 g/L and 1.081 g/L, respectively, indicating that the red light was the best light source for the growth of Spirulina as a highest growth rate with an dramatic increase of 56.69% (compared to the control group) in the dry matter content was observed.
8 hr were proved to be the best exposure time of red light for the growth of Spirulina within one day, where a dry matter content of 1.440 g/L was found. This was 67.64% higher than that of the control group. Combined light sources of red-blue light, red-green light, and blue-green light were also applied to Spirulina, and it was found that the maximum dry matter contents of Spirulina were 1.518 g/L, 1.389 g/L and 1.232 g/L for red-blue light, red-green light and blue-green light respectively. Therefore, the Spirulina exposed to red-blue light attained the highest growth rate with the corresponding dry matter content increasing by 76.72% when compared with the control group.

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WSU RESEARCH LEADS TO #ALGAE #TREATMENT FOR #BLINDNESS: Research Viewed by #Sidmans #Spirotech

[USA] In a coup for Wayne State University’s reputation as a research center, a small eye-care company RetroSense Therapeutics, that uses green algae genes to treat a type of human blindness has sold for $60 million.

Treatment Bird view: The company’s treatment uses a virus to deliver a #photoreceptor #gene from the #algae into a human patient’s eye. The research, which aims to cure an inherited disease that causes people to slowly go blind, has shown promise. The #Federal #Drug #Administration gave permission for a clinical trial.
This Company, which is now based at the Ann Arbor SPARK business accelerator, was acquired this month by Allergan, a $4 billion-a-year maker of skin and eye care products.


Research Contribution:
#Dr. Zhuo-Hua Pan of Wayne State University’s Medical School helped develop a novel treatment for a type of vision loss.
Using Pan’s discoveries, RetroSense is developing a treatment for #retinitis #pigmentosa, an inherited condition in which light receptor cells in the retina die, leading to gradual blindness or partial vision loss. The problem affects about 100,000 people in the U.S., and there have been no effective treatments.

Result Impact:
Dr. Pan’s novel research involved using a virus that delivers a #photoreceptor gene from #green #algae. Pan discovered that the gene could ultimately lead to the brain perceiving light again.  

                            

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About us

We welcome you to our future Algae startup Industry, Sidmans Spirotech Nutraceuticals India Private Limited.

About Us:
Sidmans Spirotech is an amalgamation of Agriculture, Technology, and business, Which is expanded as South Indian spirulina Industrial Development Mass production and Nutraceuticals Sciences, And it’s a future realistic project of a family of young Innovators, Establishing in 2018 with a noble aim to provide a healthy life for our present and future generation. Considering strongly that Algae as our future in terms of food and biofuel, Sidmans is moving its first step as a startup venture with respect to algal food industry. And thinking further to extend our ideas in establishing algal biofuel Industry. 

Our Vision:
Knowing the Values and importance of these Microalgae’s for this Competitive world, Sidmans Spirotech is taking its first move to establish a firm platform by producing best quality of products. Our view is to produce this novel product, Nourished with boosting agents through by utilizing advanced technologies and supplemented to the prerequisites with a view of commitment to eradicate malnourishment globally.